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本帖最后由 HZLJ 于 2023-1-29 11:56 编辑
怎么还有扣分的，乐了，辉瑞的回应我也放了，真以为我支持极右翼编的阴谋论答辩？
早上发现微博热搜第一是“辉瑞”俩字，就顺便看了下事情过程
https://www.projectveritas.com/news/pfizer-executive-mutate-covid-via-directed-evolution-for-company-to-continue/
右翼记者组织 Project Veritas 暗访辉瑞高管Jordon Trishton Walker，后者在暗访中表示（采访视频和原文见上面的链接）：
“我们为什么不干脆自己诱发新冠病毒突变，用以研发新的疫苗呢”
“我们的实验方式差不多就是往猴子身上注射病毒，并让它们相互感染，以收集序列样品”
“One of the things we [Pfizer] are exploring is like, why don't we just mutate it [COVID] ourselves so we could create -- preemptively develop new vaccines, right? So, we have to do that. If we're gonna do that though, there's a risk of like, as you could imagine -- no one wants to be having a pharma company mutating f**king viruses,” Walker said.
“From what I’ve heard is they [Pfizer scientists] are optimizing it [COVID mutation process], but they’re going slow because everyone is very cautious -- obviously they don’t want to accelerate it too much. I think they are also just trying to do it as an exploratory thing because you obviously don’t want to advertise that you are figuring out future mutations,” he said.
“Don’t tell anyone. Promise you won’t tell anyone. The way it [the experiment] would work is that we put the virus in monkeys, and we successively cause them to keep infecting each other, and we collect serial samples from them.”
“通常来说你不应该对病毒进行功能获得研究。但是（我们）现在是有正在进行的相关研究，其目的是选择病毒活性更强的突变”
“You’re not supposed to do Gain-of-Function research with viruses. Regularly not. We can do these selected structure mutations to make them more potent. There is research ongoing about that. I don’t know how that is going to work. There better not be any more outbreaks because Jesus Christ,” he said.
这段不详细翻译，这段对话中，Jordan Walker的大意是说辉瑞的科学家们在实验室中进行可控的试验，以发现任何潜在的新毒株或新变异株，并为潜在的疫苗应对做好准备。同时他认为COVID “对于我们来说是一个现金奶牛(cash cow)”
Walker:Part of what they [Pfizer scientists] want to do is, to some extent, to try to figure out, you know, how there are all these new strains and variants that just pop up. So, it’s like trying to catch them before they pop up and we can develop a vaccine prophylactically, like, for new variants. So, that’s why they like, do it controlled in a lab, where they say this is a new epitope, and so if it comes out later on in the public, we already have a vaccine working.
Veritas Journalist:Oh my God. That’s perfect. Isn’t that the best business model though? Just control nature before nature even happens itself? Right?
Walker:Yeah. If it works.
Veritas Journalist:What do you mean if it works?
Walker:Because some of the times there are mutations that pop up that we are not prepared for. Like with Delta and Omicron. And things like that. Who knows? Either way, it’s going to be a cash cow. COVID is going to be a cash cow for us for a while going forward. Like obviously.
Veritas Journalist:Well, I think the whole research of the viruses and mutating it, like, would be the ultimate cash cow.
Walker:Yeah, it’d be perfect.
这一段也不详细翻译了，大意上是Jordan Walker锐评了制药巨头高管和FDA 官员之间存在的“旋转门”关系， “旋转门”有利于制药巨头和FDA官员，但“不利于其他美国人”
Walker:[Big Pharma] is a revolving door for all government officials.
Veritas Journalist:Wow.
Walker:In any industry though. So, in the pharma industry, all the people who review our drugs -- eventually most of them will come work for pharma companies. And in the military, defense government officials eventually work for defense companies afterwards.
…
Veritas Journalist:How do you feel about that revolving door?
Walker:It’s pretty good for the industry to be honest. It’s bad for everybody else in America.
Veritas Journalist:Why is it bad for everybody else?
Walker:Because when the regulators reviewing our drugs know that once they stop regulating, they are going to work for the company, they are not going to be as hard towards the company that’s going to give them a job.
另一个右翼“独立调查记者”Brian O'Shea，对Jordon Trishton Walker是否确有其人的一些考证，主要基于纽约州医师注册系统以及领英下属网站"Signal Hire"的公开信息
https://brianoshea.substack.com/p/who-is-jordon-trishton-walker
他声称“公开信息显示Jordon Trishton Walker 确有其人，他曾先后就读于耶鲁大学和得州大学西南医学部，在2021年加入辉瑞前，曾先后在BCG，麻省总医院和IQVIA工作过”
然后来看辉瑞的官方回应
https://www.pfizer.com/news/announcements/pfizer-responds-research-claims
首先是否认了“辉瑞正在进行功能获得研究或选择性突变研究”的指控
In the ongoing development of the Pfizer-BioNTech COVID-19 vaccine, Pfizer has not conducted gain of function or directed evolution research. Working with collaborators, we have conducted research where the original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. This work is undertaken once a new variant of concern has been identified by public health authorities. This research provides a way for us to rapidly assess the ability of an existing vaccine to induce antibodies that neutralize a newly identified variant of concern. We then make this data available through peer reviewed scientific journals and use it as one of the steps to determine whether a vaccine update is required.
接着，辉瑞称：
- 作为Paxlovid有效成分之一的奈玛特韦，其对新冠病毒突变的体外有效性评估试验，通常是以计算机模拟或者体外诱导病毒蛋白酶突变的方式进行
- 病毒蛋白酶本身不具有感染能力
- 这种试验都是在BSL 3 等级的生物安全实验室中进行，且该试验是美国或者全世界法规强制要求必须进行的
In addition, to meet U.S. and global regulatory requirements for our oral treatment, PAXLOVID™, Pfizer undertakes in vitro work (e.g., in a laboratory culture dish) to identify potential resistance mutations to nirmatrelvir, one of PAXLOVID’s two components. With a naturally evolving virus, it is important to routinely assess the activity of an antiviral. Most of this work is conducted using computer simulations or mutations of the main protease–a non-infectious part of the virus. In a limited number of cases when a full virus does not contain any known gain of function mutations, such virus may be engineered to enable the assessment of antiviral activity in cells. In addition, in vitro resistance selection experiments are undertaken in cells incubated with SARS-CoV-2 and nirmatrelvir in our secure Biosafety level 3 (BSL3) laboratory to assess whether the main protease can mutate to yield resistant strains of the virus. It is important to note that these studies are required by U.S. and global regulators for all antiviral products and are carried out by many companies and academic institutions in the U.S. and around the world.
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发表于 2023-1-29 10:33
见惯不怪了，只能说这些龙头大佬就是能为所欲为，然后特效药销量只有蹭蹭上涨
不过前段时间有些狗东西的话术倒是一上来就是最新版本
，阴谋论挺喜欢的
